科研成果

课题组Mohamed博士在《Advanced Science》期刊(IF:15.1,国际顶级期刊,1区)发表Spy转座子研究论文,2024.4

课题组石莎莎博士在国际学术期刊Molecular Phylogenetics and Evolution (IF:4.1,1区)上发表Hiker转座子研究论文,2023.8

PS和ZB转座子系统及配套专利技术成果转让上海细胞治疗集团有限公司,2023.4

课题组王赛赛博士后在国际学术期刊Nucleic Acids Research (IF:14.90,2区)上发表PS转座子研究成果,2023

课题组沈丹博士在国际学术期刊Nucleic Acids Research (IF:19.16,1区)上发表ZB转座子研究成果,2021

转座子科普——微信平台

Cas9基因编辑效率提升百倍,打造基因编辑通用型改造策略,助力治疗基因疾病,2024-7

两篇Nature Chemical Biology|小尺寸大作为:IscB在基因技术领域的潜力爆发,2024-7

转座酶辅助下的高效植物基因组整合技术—TATSI-2024-7

转座子的研究现状:王露课题组-2024-7

IscB在基因技术领域的潜力爆发-2024-7

植物基因组高效无缝插入技术正式问世-2024-6

seekRNA为精确的基因编辑提供了新的技术,2024-6

新基因编辑工具SeekRNA面世-2024-6

seekRNA为精确的基因编辑提供一种新途径-2024-6

桥RNA介导的大片段基因高效精准定点整合技术-2024-7

桥RNA介导的大片段基因高效精准定点整合技术-2024-7

双特异性桥RNA介导大片段DNA的精准重排-2024-7

大片段遗传元件插入的转座子,基因编辑家族再添猛将(上)

大片段遗传元件插入的转座子,基因编辑家族再添猛将(下)

DNA转座子系统—将CAR-T细胞变成联合治疗平台

Nature | 转座子编码的核酸酶利用向导RNA促进其自身扩散

关于转座子注释的那些事-系列1

关于转座子注释的那些事(转座命名)-系列2

转座子Transposon专题

转座子——“自由移动的DNA”

Science | 张峰组解析出非长末端重复逆转录转座子起始逆转录的结构基础

转座子(TE)重头注释流程

在基因组中“跳来跳去”的转座子,有望成为免疫疗法抗击肿瘤的新靶点!

转座子杂记

转座子之母:芭芭拉•麦克林托克

转座子简介

转座元件TE在基因组上插入的选择倾向性

Life Med亮点 | 逆转座子调控人类早期胚胎发育及疾病发生

Nature重磅综述 | 逆转录转座子与衰老及老年疾病

“快得抓不住”?转座子的研究进展 | 博文精选

Nature Reviews Genetics | 转座子元件对哺乳动物染色质结构的作用

Nature重磅:转座子入侵,DNA重组,着丝粒进化,最终促进了物种形成

速度收藏!关于转座子编辑细胞株的干货

生信分析22:完整的转座子注释流程

转座子分类软件deepTE简介

相册

2024-6 王赛赛(博士后)、杨乃苏(博士)、硕士郭梦可、何佳、袁文娟、ADDY合影

2023-12-Numan and Mohamed Ph.D graduation

2023-6 王亚丽(博士)、杜站宇(博士)、贾文竹、王梦礼毕业合影

2022-6 关中夏、石莎莎、迟城林毕业合影

2021-王赛赛(博士)、宗文成、郑尧、桑亚通、安亚龙、顾浩毕业合影

2020-沈丹、产舒恒、陈子旋毕业合影

2019-6 陈才(博士)、王伟、陈伟、张丽毕业合影

2018-12 张丽毕业合影

2017-12 王亚丽、刘帅军、钟继汉毕业合影

2016-6 沈丹、薛松磊毕业合影

2015-12 王赛赛、陈才、钱跃、史云强

2014 YearBook

2013 YearBook

2013 YearBook

2012 YearBook

2011 YearBook

2010 YearBook-1

2010 YearBook-2

2009 YearBook

2008 YearBook-1

2008 YearBook-2

2007 YearBook

Key TE Reviews

Transposable elements, contributors in the evolution of organisms (from an arms race to a source of raw materials), Heliyon. 2021. PMID: 33532648.

Specificities and Dynamics of Transposable Elements in Land Plants. Biology (Basel). 2022. PMID: 35453688

A Field Guide to Eukaryotic Transposable Elements. Annu Rev Genet. 2020. PMID: 32955944.
A survey of transposable element classification systems–a call for a fundamental update to meet the challenge of their diversity and complexity. Mol Phylogenet Evol. 2015. PMID: 25797922.
All Quiet on the TE Front? The Role of Chromatin in Transposable Element Silencing. Cells. 2022. PMID: 36010577.
An epigenetic toolkit allows for diverse genome architectures in eukaryotes. Curr Opin Genet Dev. 2015. PMID: 26649755.
Bridging multiple dimensions: roles of transposable elements in higher-order genome regulation. Curr Opin Genet Dev. 2023. PMID: 37028152.
Coevolution between transposable elements and recombination. Philos Trans R Soc Lond B Biol Sci. 2017. PMID: 29109221.
Constitutive Heterochromatin in Eukaryotic Genomes: A Mine of Transposable Elements. Cells. 2022. PMID: 35269383.
Dark genome, bright ideas: Recent approaches to harness transposable elements in immunotherapies. Cancer Cell. 2022. PMID: 35907399.
Distinguishing friends, foes, and freeloaders in giant genomes. Curr Opin Genet Dev. 2018. PMID: 29544119.
Diversity and evolution of transposable elements in Arabidopsis. Chromosome Res. 2014. PMID: 4801342.
Double-edged sword: The evolutionary consequences of the epigenetic silencing of transposable elements. PLoS Genet. 2020. PMID: 32673310.
Epigenetic regulation of intragenic transposable elements: a two-edged sword. J Biochem. 2018. PMID: 30010918.
Evolution of transposable elements and evolution of eukaryote genomes mediated by transposable elements. Genes Genet Syst. 2019. PMID: 31996493.
Evolutionary impact of transposable elements on genomic diversity and lineage-specific innovation in vertebrates. Chromosome Res. 2015. PMID: 26395902.
Giant Transposons in Eukaryotes: Is Bigger Better? Genome Biol Evol. 2019. PMID: 30796812.
Horizontal acquisition of transposable elements and viral sequences: patterns and consequences. Curr Opin Genet Dev. 2018. PMID: 29505963.
Horizontal transfers of transposable elements in eukaryotes: The flying genes. C R Biol. 2016. PMID: 27234293.
Host Gene Regulation by Transposable Elements: The New, the Old and the Ugly. Viruses. 2020. PMID: 32993145.
Host-transposon interactions: conflict, cooperation, and cooption. Genes Dev. 2019. PMID: 31481535.
How retrotransposons shape genome regulation. Curr Opin Genet Dev. 2016.PMID: 26855260.
Impact of transposable elements on the evolution of complex living systems and their epigenetic control. Biosystems. 2021. PMID: 34718084.
Integration of TE Induces Cancer Specific Alternative Splicing Events. Int J Mol Sci. 2022. PMID: 36142830.
Integration site selection by retroviruses and transposable elements in eukaryotes. Nat Rev Genet. 2017. PMID: 28286338.
Investigating the Potential Roles of SINEs in the Human Genome. Annu Rev Genomics Hum Genet. 2021. PMID: 33792357.
Jumping the fine LINE between species: horizontal transfer of transposable elements in animals catalyses genome evolution. Bioessays. 2013. PMID: 24003001.
Mammalian genome evolution as a result of epigenetic regulation of transposable elements. Biomol Concepts. 2014. PMID: 25372752.
Mammalian genome innovation through transposon domestication. Nat Cell Biol. 2022. PMID: 36008480.
Mammalian transposable elements and their impacts on genome evolution. Chromosome Res. 2018. PMID: 29392473.
Massive contribution of transposable elements to mammalian regulatory sequences. Semin Cell Dev Biol. 2016. PMID: 27174439.
Methodologies for the De novo Discovery of Transposable Element Families. Genes (Basel). 2022. PMID: 35456515.
Mobility connects: transposable elements wire new transcriptional networks by transferring transcription factor binding motifs. Biochem Soc Trans. 2020. PMID: 32573687.
More than causing (epi)genomic instability: emerging physiological implications of transposable element modulation. J Biomed Sci. 2021. PMID: 34364371.
New Insights on the Evolution of Genome Content: Population Dynamics of Transposable Elements in Flies and Humans. Methods Mol Biol. 2019. PMID: 31278675.
On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses. Genes (Basel). 2019. PMID: 30935103
Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements. Front Genet. 2022. PMID: 35646069.
Regulatory activities of transposable elements: from conflicts to benefits. Nat Rev Genet. 2017. PMID: 27867194
Repetitive elements in aging and neurodegeneration. Trends Genet. 2023. PMID: 36935218.
Retrotransposons as a Source of DNA Damage in Neurodegeneration. Front Aging Neurosci. 2022. PMID: 35058771.
Rewiring of chromatin state and gene expression by transposable elements. Dev Growth Differ. 2021. PMID: 34050925.
Role of Transposable Elements in Gene Regulation in the Human Genome. Life (Basel). 2021. PMID: 33557056.
Role of Transposable Elements in Genome Stability: Implications for Health and Disease. Int J Mol Sci. 2022. PMID: 35887150.
Roles of Transposable Elements in the Different Layers of Gene Expression Regulation. Int J Mol Sci. 2019. PMID: 31731828.
Roles of transposable elements in the regulation of mammalian transcription. Nat Rev Mol Cell Biol. 2022. PMID: 35228718.
Silencing of Transposable Elements by piRNAs in Drosophila: An Evolutionary Perspective. Genomics Proteomics Bioinformatics. 2017. PMID:28602845.
Structural and sequence diversity of eukaryotic transposable elements. Genes Genet Syst. 2020. PMID: 30416149.
Taming the Turmoil Within: New Insights on the Containment of Transposable Elements. Trends Genet. 2020. PMID: 32473745.
Taming transposable elements in vertebrates: from epigenetic silencing to domestication. Trends Genet. 2022. PMID: 35307201.
Taming, Domestication and Exaptation: Trajectories of Transposable Elements in Genomes. Cells. 2021. PMID: 34944100.
TFs for TEs: the transcription factor repertoire of mammalian transposable elements. Genes Dev. 2021. PMID: 33397727.
The challenges of predicting transposable element activity in hybrids. Curr Genet. 2021. PMID: 33738571.
The evolution and function of transposons in epigenetic regulation in response to the environment. Curr Opin Plant Biol. 2022. PMID: 35961279.
The Evolutionary Volte-Face of Transposable Elements: From Harmful Jumping Genes to Major Drivers of Genetic Innovation. Cells. 2021. PMID: 34831175.
The impact of transposable elements in genome evolution and genetic instability and their implications in various diseases. Genomics Inform. 2014. PMID: 25317108.
The impact of transposable elements on gene functionality and genomic structural variations. Genesis. 2020. PMID: 33230956.
The impact of transposable elements on mammalian development. Development. 2016. PMID: 27875251.
The important contribution of transposable elements to phenotypic variation and evolution. Curr Opin Plant Biol. 2022. PMID: 34883307.
The Intricate Evolutionary Balance between Transposable Elements and Their Host: Who Will Kick at Goal and Convert the Next Try? Biology (Basel). 2022. PMID: 35625438.
The Mobilome of Reptiles: Evolution, Structure, and Function. Cytogenet Genome Res. 2019. PMID: 30739120.
The power of “controllers”: Transposon-mediated duplicated genes evolve towards neofunctionalization. J Genet Genomics. 2023. PMID: 37068629.
The role of transposable elements in aging and cancer. Biogerontology. 2023. PMID: 37017895.
The role of transposable elements in health and diseases of the central nervous system. J Neurosci. 2013. PMID: 24198348.
The Role of Transposable Elements of the Human Genome in Neuronal Function and Pathology. Int J Mol Sci. 2022. PMID: 35628657.
The Structural, Functional and Evolutionary Impact of Transposable Elements in Eukaryotes. Genes (Basel). 2021. PMID: 34203645.
Transposable Element Dynamics and Regulation during Zygotic Genome Activation in Mammalian Embryos and Embryonic Stem Cell Model Systems. Stem Cells Int. 2021. PMID: 34691189.
Transposable Element Mediated Innovation in Gene Regulatory Landscapes of Cells: Re-Visiting the “Gene-Battery” Model. Bioessays. 2018. PMID: 29206283.
Transposable Elements and Human Diseases: Mechanisms and Implication in the Response to Environmental Pollutants. Int J Mol Sci. 2022. PMID: 35269693.
Transposable elements and their role in aging. Ageing Res Rev. 2023. PMID: 36773759.
Transposable elements as a potent source of diverse cis-regulatory sequences in mammalian genomes. Philos Trans R Soc Lond B Biol Sci. 2020. PMID: 32075564
Transposable Elements as a Source of Novel Repetitive DNA in the Eukaryote Genome. Cells. 2022. PMID: 36359770.
Transposable elements as essential elements in the control of gene expression. Mob DNA. 2023. PMID: 37596675
Transposable elements as genetic accelerators of evolution: contribution to genome size, gene regulatory network rewiring and morphological innovation. Genes Genet Syst. 2020. PMID: 31932541.
Transposable elements as new players in neurodegenerative diseases. FEBS Lett. 2021. PMID: 34626428.
Transposable Elements Co-Option in Genome Evolution and Gene Regulation. Int J Mol Sci. 2023. PMID: 36768929.
Transposable elements in Drosophila. Mob Genet Elements. 2017. PMID: 28580197.
Transposable Elements in Pluripotent Stem Cells and Human Disease. Front Genet. 2022. PMID: 35719395.
Transposable elements shape the evolution of mammalian development. Nat Rev Genet. 2021. PMID: 34354263.
Transposable elements, genome evolution and transgenerational epigenetic variation. Curr Opin Genet Dev. 2018. PMID: 29525544.
Transposable elements: all mobile, all different, some stress responsive, some adaptive? Curr Opin Genet Dev. 2018. PMID: 29705597.
Transposable elements: genome innovation, chromosome diversity, and centromere conflict. Chromosome Res. 2018. PMID: 29332159.
Transposable Elements: Major Players in Shaping Genomic and Evolutionary Patterns. Cells. 2022. PMID: 35326499.

PubGeneEditingTools

Editing Efficiency Prediction

TnpB Editing Efficiency Predictor (TEEP): https://go.tnpb.app/

Protein Mutational Effect Predictor (ProMEP): https://github.com/wenjiegroup/ProMEP

CRISPR

Chopchop: http://chopchop.cbu.uib.no/

CCTOP: CCTop – CRISPR/Cas9 target online predictor (uni-heidelberg.de)

CRISPR-CAS++ (paris-saclay.fr)

CRISPRone (indiana.edu)

CRISPRmap (uni-freiburg.de)

CRISPRDetect (otago.ac.nz)

CRISPRloci – CRISPR-Cas annotation (uni-freiburg.de)

crisprSQL – CRISPR off-target database

CRISPR RGEN Tools (rgenome.net)

https://chopchop.cbu.uib.no/

https://benchling.com/pub/c2c2

http://crispr-analyzer.dkfz.de/

http://www.e-crisp.org/E-CRISP/

http://crispresso.pinellolab.org/submission

http://guides.sanjanalab.org/#/

https://www.crisprindelphi.design/

Tools – brounslab

Addgene: CRISPR Plasmids and Resources

TALEN

Tools | TAL Effector Nucleotide Targeter 2.0 (cornell.edu)

http://www.e-talen.org/

Mojo Hand (talendesign.org)

TALENoffer – Jstacs

SAPTA TAL Targeter | Tools | tDnA (rice.edu)

ZNF

DeepZF

ZFNGenome

ZiF PREDICTION

Zibase

Zinc Finger Tools (scripps.edu)

The Zinc Finger Consortium | Software Tools (zincfingers.org)

GitHub – OrensteinLab/DeepZF

Predicting DNA Recognition – Main Menu (princeton.edu)

PubDatabase

Mobilome Database

RepBase: https://www.girinst.org/repbase/update/index.html

Dfam: https://dfam.org/browse

ISfinder: https://www-is.biotoul.fr/index.php

GYDB: http://gydb.org/index.php/Collection_alignments

Tncentral: https://tncentral.ncc.unesp.br/TnPedia/index.php/Main_Page

mobileOG-db: https://mobileogdb.flsi.cloud.vt.edu/

TE hub: https://tehub.org/classification/telineages

MsReDB: https://msrepdb.cbrc.kaust.edu.sa/pages/msRepDB/index.html

FISHTEDB: https://www.fishtedb.com/

PlantRep: http://www.plantrep.cn/

ICEberg: https://bioinfo-mml.sjtu.edu.cn/ICEberg2/index.php

Human RIP: http://dbrip.brocku.ca/

RICE RIP: http://ibi.zju.edu.cn/Rtrip/download.html#

L1 Database: l1base.charite.de

LINE-1 associated neurodegenerative disease gene therapy company: https://www.transposonrx.com/

Tn registry: https://transposon.lstmed.ac.uk/tn-registry

ERV: http://geve.med.u-tokai.ac.jp/

ERV: https://herv.img.cas.cz/

Using Transposons in the Lab:https://blog.addgene.org/plasmids-101-using-transposons-in-the-lab

Gene Engineering Services With TcBuster: https://www.bio-techne.com/services/gene-engineering-services

piggyBac: Wayback Machine (archive.org)

P element: P Elements in Drosophila

RNA

NONCODE

ncRNA databases

RNACentral

Rfam

rRNA

noncoRNA

cncRNAdb

non-coding RNA database resources

Bioinformatics Tools and Databases for Functional RNA Analysis

GtRNAdb

Protein

AlphaFold Protein Structure Database

InterPro

Pfma: http://pfam.xfam.org/

Yeast Genome Database: Saccharomyces Genome Database | SGD (yeastgenome.org)

The Genetic Codes:https://www.ncbi.nlm.nih.gov/Taxonomy/Utils/wprintgc.cgi

Zebrafish

Chengyi Song Lab

Danio-Code:Ferenc Muller

Society for Zebrafish Research

OtherTools

TE annotation

MGERT: Mobile Genetic Elements Retrieving Tool

Generic Repeat Finder: A High-Sensitivity Tool for Genome-Wide De Novo Repeat Detection

TransposonUltimate-2022: software for transposon classification, annotation and detection

Earl Grey-2024: A Fully Automated User-Friendly Transposable Element Annotation and Analysis Pipeline

Genome ARTIST_v2-An Autonomous Bioinformatics Tool for Annotation of Natural Transposons in Sequenced Genomes

Transposable Element Finder – Detection of active transposable elements from NGS data

HiTE-2024: a fast and accurate dynamic boundary adjustment approach for full-length transposable element detection and annotation

Transposome-2015: a toolkit for annotation of transposable element families from unassembled sequence reads

RepeatFiller-2019: newly identifies megabases of aligning repetitive sequences and improves annotations of conserved non-exonic elements

ERVcaller

reputils: A small collection of command line functions to deal with TE alignments.

repeatR: read and analyse RepeatMasker output

RepBox-2023: a toolbox for the identification of repetitive elements

TARGeT: Tree Analysis of Related Genes and Transposons

TIR detection

IRF-2025-updated: Inverted Repeats Finder

MUSTv2-2017: An Improved De Novo Detection Program for Recently Active Miniature Inverted Repeat Transposable Elements (MITEs)

MiteFinderII-2018: a novel tool to identify miniature inverted-repeat transposable elements hidden in eukaryotic genomes

MITE Tracker-2018: An accurate approach to identify miniature inverted-repeat transposable elements in large genomes

IUPACpal-2021: efficient identification of inverted repeats in IUPAC-encoded DNA sequences

detectIR-2016-updated: detectIR download | SourceForge.net

gt-tirvish – Identify Terminal Inverted Repeat (TIR) elements,such as DNA transposons.

Lirex-2017: A Package for Identification of Long Inverted Repeats in Genomes

detectMITE-2016: A novel approach to detect miniature inverted repeat transposable elements in genomes

MITE-Hunter-2010: a program for discovering miniature inverted-repeat transposable elements from genomic sequences

MITE Digger-2013, an efficient and accurate algorithm for genome wide discovery of miniature inverted repeat transposable elements

TIRfinder-2013: A Web Tool for Mining Class II Transposons Carrying Terminal Inverted Repeats

TIR-Learner: Modified TIR-Learner for Rice genome

TIR-Learner v3: New generation TE annotation program for identifying TIRs

TSDfinder: The TSDfinder tool identifies TSDs plus non-LTR retrotransposon-driven transductions.

Gene/ORF and domain Prediction

Promoter: https://molbiol-tools.ca/Promoters.htm

GeneMark (Prokaryotic ): GeneMark gene prediction (gatech.edu)

Prodigal (Prokaryotic): Fast, reliable protein-coding gene prediction for prokaryotic genomes

Genscan: New GENSCAN Web Server at MIT

GetORF: EMBOSS: getorf (bioinformatics.nl)

ORFfinder: ORFfinder Home – NCBI (nih.gov)

Genome tool

tRNA database: http://gtrnadb.ucsc.edu/index.html

Rfam: https://rfam.org/

xfam:http://pfam-legacy.xfam.org/

InterPro:https://www.ebi.ac.uk/interpro/

Ensemble: https://www.ensembl.org/index.html

Animal Genome Size: Animal Genome Size Database:: Home

Genome browse: https://www.ncbi.nlm.nih.gov/genome/browse

Galaxy: https://usegalaxy.org/?msclkid=038ffcd4b64211eca081527e1ddb66da

BARCH ENTREZ: https://www.ncbi.nlm.nih.gov/sites/batchentrez

Clustal Omega: https://www.ebi.ac.uk/Tools/msa/clustalo/

EMBOSS: http://www.bioinformatics.nl/emboss-explorer/

CD-HIT: http://weizhong-lab.ucsd.edu/cdhit_suite/cgi-bin/index.cgi

USEARCH: https://drive5.com/

SeqLogo: http://weblogo.berkeley.edu/logo.cgi

Tree

TimeTree: http://www.timetree.org/

TolTree: http://tolweb.org/tree/

Lifemap: http://lifemap-ncbi.univ-lyon1.fr/

RNA

RNA-Protein Interaction Prediction (RPISeq)

hybridRNAbind

RStrucFam

PredRBR

omiXcore: a web server for prediction of protein interactions with large RNA

Protein tools and server

SMART: Simple Modular Architecture Research Tool

Expasy: Swiss Institute of Bioinformatics

STRING: a database of known and predicted protein-protein interactions

EVOLVE: Evolutionary Variation Observation Learning and Variant Exploration

*DNA binding motif prediction: https://predictprotein.org/

GraphSite: AlphaFold2-aware protein-DNA binding site prediction using graph transformer

DeepPBS

DP-Bind: a web server for sequence-based prediction of DNA-binding residues in DNA-binding proteins.

DNABIND: DNA Binding Protein prediction

DNA Binding Motifs: USING DATABASES & CREATING YOUR OWN

MOTIF: https://www.genome.jp/tools/motif/

iDNAProt-ES

Predict Zinc Binding

Zinc finger proteins (ZFP)

ZnF-Prot: Zinc finger motifs in proteome

DNA binding site predictor for Cys2His2 Zinc Finger Proteins: Predicting DNA Recognition

ZiF-predict

MPI Bioinformatics Toolkit

Transposase domains prediction: NCBI Conserved Domain Search (nih.gov)

HMMsearch: https://www.ebi.ac.uk/Tools/hmmer//search/phmmer

Alphafold: https://alphafold.ebi.ac.uk/search/organismScientificName/Escherichia%20coli%20%28strain%20K12%29

PDB: https://www.rcsb.org/

HADDOCK2.4:https://wenmr.science.uu.nl/haddock2.4/

DNA and RNA fold

RNAfold web server

DNA Folding Form

Internal Link

Storage: kodbox.mobilome.cn

ChatGPT 学术优化 (mobilome.cn)

Website: Mobilome Lab

博士及博士后招聘

一、博士及博士后研究方向

研究方向1:靶向DNA转座子挖掘及高效安全载体递送技术研发
主要开展靶向DNA转座子挖掘、活性转座子验证筛选、系统优化和转座酶定向进化,为人类基因治疗和生物转基因研究提一种安全高效的靶向非病毒载体递送系统,为实现较大基因片段在细胞基因组中的高效定点整合,破解制约众多基因治疗和基因组改造应用的关键瓶颈,释放其在生物转基因育种和基因治疗等应用方向巨大潜力提供技术积累。

研究方向2:转座子起源小分子靶向核酸酶挖掘及基因编辑工具开发
通过对原核生物基因组大数据挖掘,揭示IS605,IS607和IS1341转座子起源小分子核酸酶(TnpB和IscB)的系统进化和结构特征,筛选具有开发潜力的小分子核酸酶进行定向进化、分子重构,研发基因编辑效率高、靶向特异性强的新型基因编辑工具,为人类基因治疗和转基因生物育种提供更加安全高效的编辑系统。

研究方向3:基于猪基因组中活性逆转座子插入多态(RIP)为基础的分子标记研发、RIP液相芯片及育种应用评估
主要开展猪等家畜基因组转座子注释,逆转座子介导产生分子标记(也称为转座子插入多态RIP,Retrotransposon insertion polymorphism)规模挖掘及其遗传效应研究,RIP标记配套液相芯片研发及其在育种中的应用评估。

二、博士申请(硕博连读和申请考核)要求

参照学校和学院每年发布的当年申请要求,一般应达到以下要求:

硕博连读基本条件
(一)拥护中国共产党的领导,具有正确的政治方向,热爱祖国,愿意为社会主义现代化建设服务,遵纪守法,品行端正。无任何考试作弊、学术剽窃及其它违法违纪行为。
(二)身体和心理健康状况符合我校体检要求。按照教育部、卫生部、中国残联印发的《普通高等学校招生体检工作指导意见》(教学〔2003〕3号)、《教育部办公厅卫生部办公厅关于普通高等学校招生学生入学身体检查取消乙肝项目检测有关问题的通知》(教学厅〔2010〕2号)规定执行。
(三)英语水平。通过CET-4或具有一年及以上的国外留学经历。
(四)学分课(学术型、专业型分别排名)成绩排名年级前50%,且没有考试不及格的课程。
(五)在满足上述条件的前提下,英语通过CET-6,或近三年雅思(IELTS)成绩≥6.5分或托福(TOEFL)成绩≥85或GRE成绩≥260;或以第一作者发表SCI论文(需Online,截止日期12月31日);或授权发明专利(排名前2名,截止日期12月31日)者,优先考虑。

申请考核基本要求
专业考核包括申请者科研成果、英语水平审核和面试考核。
(一)科研成果
1.以第一作者身份发表SCI收录论文1篇,或CSCD(核心库)收录论文1篇,或北大中文核心收录论文2篇;
2.在满足条件1的前提下,有授权发明专利(排名前2名)者优先。
(二)英语水平
英语水平达到以下条件之一:
1.提供以下至少一项英语考试的成绩证明,具体包括:国家CET-6成绩≥426分,或近三年雅思(IELTS)成绩≥6.5分或托福(TOEFL)成绩≥85(老TOEFL成绩≥560分);
2.在英语国家或地区获得硕士学位;
3.具有一年及以上的英语国家国外留学经历;
4.发表SCI三区(中科院分区)以上(含三区)论文1篇,且国家CET-4成绩≥426分。

三、博士后招聘要求

1、具有博士学位,品学兼优,身体健康,年龄不超过35周岁。
2、获得博士学位年限不超过两年。
3、全职全时,不招收在职博士后。
4、专业背景(生物学、遗传学、发育生物学、细胞生物学、生物化学与分子生物学、生物物理学、生物信息学、动物遗传育种),熟悉哺乳动物细胞培养或者生物信息学分析优先考虑。
5、学术要求(以下两项需满足一项即可):
(1)申请师资博士后需以第一作者在SCI期刊上发表论文至少2篇,且Top期刊研究论文1篇,或一区研究论文1篇。
(2)申请全职博士后需以第一作者在SCI期刊上发表研究论文2篇或二区以上研究论文1篇。
6、符合扬州大学博士后管理的规定

四、博士后应聘材料

1、个人简历,包括个人基本情况、学习工作经历、主要研究工作内容、博士在学期间发表的第一作者论著清单(SCI收录文章需注明影响因子)、获得的奖励情况。
2、博士学位证书、毕业证书(应届毕业生可于毕业后补发)。
3、博士论文全文PDF版(应届毕业生可于毕业后补发)。
4、博士在学期间发表的第一作者SCI收录论著全文。
5、两封专家推荐信(包括博士导师的推荐信)。
6、博士后工作期间研究设想。

五、待遇

1、博士的奖助学金参照学校和学院说明。

2、博士后按照扬州大学相关福利待遇规定执行,税前基本年薪25-30万元/年,详见学校博士后工作 (yzu.edu.cn)
2、在享受学校相关待遇基础上,课题组将另提供与其业绩相称的年终绩效奖励。

六、应聘方式

1、招聘长期有效,有意向者,请将详细的个人简历(包括完整的学习工作经历及代表成果清单)以邮件形式发送,邮件主题注明“申请扬州大学转座子实验室博士后/博士”;
2、联系人:宋老师 Email:cysong@yzu.edu.cn

国外学术岗位招聘

Job in Bioloxy

https://professorpositions.com/n1388548

学校规章制度

  • 课题组研究生成果奖励制度等(2025年试行)
  • 一、博士后、博、硕士研究生申请学位论文发表要求
  • 国内博士后至少发表1篇5分以上SCI研究论文(或者1区),积极申请国家、江苏省博士后基金、国家自然科学基金青年基金
  • 博士研究生发表2篇以上SCI研究论文,其中至少1篇3区以上
  • 硕士研究生发表1篇SCI研究论文
  • 二、研究生成果奖励制度
  • 论文奖励
  • 1区论文第1、2、3作者分别奖励:3000元/篇、1000元/篇、500元/篇
  • 2区论文第1、2、3作者分别奖励:1500元/篇、500元/篇
  • 3区论文第1、2作者分别奖励:1000元/篇、500元/篇
  • 4区及以下论文(含EI收录论文)第1作者奖励:800元/篇
  • 第1作者在北京大学《中文核心期刊要目总览》中的学术期刊上发表的论文500元/篇。
  • 注:
  • 在学校顶尖期刊杂志发表的论文,第1作者追加6000元/篇奖励,在学校顶级期刊杂志发表的论文,第1作者追加4000元/篇奖励,在SCI影响因子10以上杂志发表的论文,第1作者追加3000元/篇奖励,不累加,按照最高标准奖励。
  • SCI分区以当年中科院分区为准,SCI影响因子依据当年发布为准
  • 第2、3作者在论文奖励时,需要申报在发表论文中所作贡献,并经导师和第1作者确认贡献大小,如贡献很小或者无贡献则降低奖励标准或者不奖励。
  • 导师排名在前3不影响对论文有贡献学生的奖励,参照以上标准顺沿奖励除导师外排名前3学生。
  • 论文奖励发放以正式录用为准。
  • 其它奖励(专利、研究生创新计划项目资助和优秀毕业论文奖励等)
  • 申请发明专利并获得受理的主要完成人(除老师外,学生前2名),1000元/项,按照排名分别按70%:30%比例分配,如其他人确有较大贡献酌情奖励。
  • 研究生获得科研创新计划项目(第1申请人)省资助,1000元/项,校资助,500元/项,博士后获得全国博士后基金一般资助项目2000元/项,特别资助项目5000元/项,国家青年基金项目5000元/项。
  • 参加国内二级学会以上主办的会议作报告,400元/次,论文获奖,800元/篇。
  • 毕业后获得省级优秀论文追加奖励,省级优秀博士论文(3000元/篇),省级优秀硕士学位论文(1000元/篇)、本实验室硕士获得省级优秀本科毕业论文(1000元/篇)
  • 三、考勤和补助发放制度
  • 考勤时间:开学时间上午8:30,下午2:30,寒暑期间上午9:00,下午2:30,出勤率达80%以上为考勤合格
  • 博士研究生基础补助600元/月+绩效补助400元/月
  • 硕士研究生基础补助300元/月+绩效补助200元/月
  • 圆满完成值日任务,考勤合格,方可发放基础补助
  • 完成每月科研目标任务,方可发放绩效补助。
  • 四、读书报告及进展汇报安排
  • 博士、硕士研究生每周认真准备PPT,并汇报进展
  • Journal Club: 博士后、博士、硕士(志愿参加)轮流做英文读书报告(每周1人)
  • Postdocs and PhD students will take turns to present journal club reports in English (one person per week, after lab meeting), Master Volunteers are welcome to participate.
  • 读书报告文章除导师指定外,应为当年和上一年度发表的文章,IF>=5
  • Articles for the journal club reports should be from the current year or the previous year, with an Impact Factor (IF) of at least 5, unless specified by the supervisor.
  • 五、其它若干公约、制度
  • 本实验室所有成员应互帮互助、团结协作、服从管理,积极参与卫生清洁等公益工作,维护环境整洁优美,故意制造矛盾,无事生非,破坏实验室团结者取消在本实验室开展工作权利;
  • 任何时间不得在学习室和实验室玩游戏,发现1次者停发2个月补助,发现2次者,暂停培养,约谈家长;
  • 任何人不得在工作时间在学习室和实验室看电影、电视等视频,发现1次者停发1个月补助;
  • 研究生负责对指导的本科生进行安全、卫生等制度的教育,纪律制度参照研究生标准,不能认真执行且屡教不改者,中止实验,另择导师。
  •  
  • 学校制度
  • 扬州大学专利管理办法
  • 扬州大学申请博士学位的科研成果基本要求
  • 扬州大学博士后管理工作规定
  • 关于印发《扬州大学博士研究生指导教师招生工作实施细则(修订)》的通知
  • 关于印发《扬州大学博士研究生“申请考核制”招生实施办法(修订)》的通知
  • 关于印发《扬州大学博士研究生招生管理办法(修订)》的通知
  • 中国科学院文献情报中心发布的《国际期刊预警名单(试行)》-2022
中国科学院文献情报中心发布的《国际期刊预警名单(试行)》-2022